Publication: Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration
Authors
Navone, Stefania Elena ; Marfia, Giovanni ; Giannoni, Amedeo ; Beretta, Matteo ; Guarnaccia, Laura ; Gualtierotti, Roberta ; Nicoli, Daniele ; Rampini, Paolo ; Campanella, Rolando
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI 10.14670/HH-11-846
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info:eu-repo/semantics/article
Description
Abstract
Intervertebral disc (IVD) degeneration (IDD)
is one of the major causes of back pain, a condition that
represents a serious socio-economic burden. Deeper
knowledge of the complex and fine relationship between
IVD degeneration, tissue inflammation and pain, appears
to be critical to improve the current therapies, which
have so far proven themselves ineffective. Upon
degeneration, IVD tissues become inflamed, and this
inflammatory microenvironment is associated with a
cascade of degenerative events that may eventually
cause discogenic pain. In particular, several studies have
highlighted the major role of a number of proinflammatory mediators not only in the onset of the
inflammatory condition, but also in the development of
IDD in general. In this review, we will present the main
pathological events that occur during disc degeneration,
focusing on the relationship between the abnormal
inflammatory milieu of the degenerating IVD, IDD and
the generation of pain. Finally, we will present the
current therapies for the treatment of IDD and low back
pain, and the perspectives of future, more effective
therapies.
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Citation
Histology and Histopathology, Vol.32, nÂş6, (2017)
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