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Expression of p53 and isoforms in beningn and malignant lesions of the head and neck

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dc.contributor.authorTrovato, M.C.
dc.contributor.authorRuggeri, R.M.
dc.contributor.authorGuzzo, E.
dc.contributor.authorCerto, R.
dc.contributor.authorAlibrandi, A.
dc.contributor.authorScifo, S.
dc.contributor.authorScardigno, M.
dc.contributor.authorVitarelli, E.
dc.contributor.authorArena, G.
dc.contributor.authorGambadoro, O.
dc.contributor.authorCatalano, N.
dc.contributor.authorBourdon, J.C.
dc.contributor.authorGalletti, B.
dc.contributor.authorGalletti, F.
dc.contributor.authorCavallari, V.
dc.date.accessioned2022-02-17T09:46:35Z
dc.date.available2022-02-17T09:46:35Z
dc.date.issued2017
dc.description.abstractBackground. P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined. Methods. By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21). Results. In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immunoexpression of P53 and related isoforms was double in SCC compared to IPA (10% vs 24%), while expression of P53 isoforms was strongly reduced (70% vs 43%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms. Conclusions. We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.32, nÂş4, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-802
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117127
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectP53es
dc.subjectP53 isoformses
dc.subjectImmunohistochemistryes
dc.subjectBenign and malignant squamous lesionses
dc.subjectHead and neck carcinogenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleExpression of p53 and isoforms in beningn and malignant lesions of the head and neckes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nÂş4 (2017)