Publication:
Therapeutic roles of PPARα activation in ocular ischemic diseases

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dc.contributor.authorLee, Deokho
dc.contributor.authorTomita, Yohei
dc.contributor.authorNegishi, Kazuno
dc.contributor.authorKurihara, Toshihide
dc.date.accessioned2023-03-29T11:12:02Z
dc.date.available2023-03-29T11:12:02Z
dc.date.issued2023
dc.description.abstractOcular ischemia is one of the leading causes of blindness. It is related to various ocular diseases and disorders, including age-related macular degeneration, diabetic retinopathy, glaucoma, and corneal injury. Ocular ischemia occurs due to an abnormal supply of oxygen and nutrients to the eye, resulting in ocular metabolic dysfunction. These changes can be linked with pathologic conditions in the eye, such as inflammation, neovascularization, and cell death, ultimately leading to vision loss. The current treatment care for ocular ischemia is limited. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor protein functioning in regulating lipid metabolism, fatty acid oxidation, and glucose homeostasis. Recently, PPARα activation has been suggested as a useful therapeutic target in treating ocular ischemia. However, its applications have not been well summarized. In this review, we cover an overview of the therapeutic roles of PPARα activation in various ocular ischemic conditions with recent experimental evidence and further provide clinical implications of its therapeutic applications. Our review will enable more approaches to comprehensively understand the therapeutic roles of PPARα activation for preventing ocular ischemic diseases.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.38, nº4, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-542
dc.identifier.urihttp://hdl.handle.net/10201/129707
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPeroxisome proliferator-activated receptor α (PPARα)es
dc.subjectFibroblast growth factor 21 (FGF21)es
dc.subjectOcular ischemiaes
dc.subjectPemafibratees
dc.subjectFenofibratees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTherapeutic roles of PPARα activation in ocular ischemic diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº4 (2023)