Publication: Therapeutic roles of PPARα activation in ocular ischemic diseases
Authors
Lee, Deokho ; Tomita, Yohei ; Negishi, Kazuno ; Kurihara, Toshihide
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-18-542
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info:eu-repo/semantics/article
Description
Abstract
Ocular ischemia is one of the leading causes
of blindness. It is related to various ocular diseases and
disorders, including age-related macular degeneration,
diabetic retinopathy, glaucoma, and corneal injury.
Ocular ischemia occurs due to an abnormal supply of
oxygen and nutrients to the eye, resulting in ocular
metabolic dysfunction. These changes can be linked with
pathologic conditions in the eye, such as inflammation,
neovascularization, and cell death, ultimately leading to
vision loss. The current treatment care for ocular
ischemia is limited. Peroxisome proliferator-activated
receptor α (PPARα) is a nuclear receptor protein
functioning in regulating lipid metabolism, fatty acid
oxidation, and glucose homeostasis. Recently, PPARα
activation has been suggested as a useful therapeutic
target in treating ocular ischemia. However, its
applications have not been well summarized. In this
review, we cover an overview of the therapeutic roles of
PPARα activation in various ocular ischemic conditions
with recent experimental evidence and further provide
clinical implications of its therapeutic applications. Our
review will enable more approaches to comprehensively
understand the therapeutic roles of PPARα activation for
preventing ocular ischemic diseases.
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Citation
Histology and Histopathology, Vol.38, nº4, (2023)
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