Publication: Monoclonal antibody against histiocytosis X cells
Authors
Ishikawa, Makoto ; Matsuda, Mikio ; lmai, Yutaka
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Monoclonal antibody against histiocytosis
X cells (HXCs) was established. The antigen was the
cell membrane of HXCs from the submandibular lesion
of a 63-year-old man who had been dignosed as an adult
type of histiocytosis X (HX) and whose HXCs had
numerous Birbeck granules (BGs). The obtained
monoclonal antibody, named MI1, reacted with the
antigenic cell membrane of HXC. Immunoblotting
showed that MI1 bound to the cell membrane of 28500
mw. MI1 also reacted with interdigitating reticulum
cells (IDCs) in the tonsil and Langerhans cells (LCs) in
the epidermis. MI1 reacted with the BGs which
connected to the cell membrane, but not with those
located near the nucleus.
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Citation
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