Publication: Effects of Orchidectomy in Selective Biochemical Analytes in Beagle Dogs
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Date
2011-03-01
Authors
Tvarijonaviciute, Asta ; Martínez Subiela, Silvia ; Carrillo Sánchez, J. D. ; Tecles Vicente, Fernando ; Cerón Madrigal, José Joaquín
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Facultades de la UMU::Facultad de Veterinaria
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Publisher
Blackwell Verlag GmbH
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DOI
https://doi.org/10.1111/j.1439-0531.2011.01765.x
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info:eu-repo/semantics/article
Description
Abstract
El objetivo de este estudio fue evaluar los posibles efectos de la orquiectomía y los cambios hormonales asociados sobre las concentraciones circulantes de proteínas de fase aguda (APPs) (CRP – proteína C reactiva; Hp – haptoglobina; Cp – ceruloplasmina), adiponectina e IGF-1 en perros. Para ello, un total de cinco perros adultos de raza Beagle fueron sometidos a orquiectomía. Se tomaron muestras de sangre antes de la castración, durante seis días consecutivos y en las semanas 2, 4, 8 y 12 tras la cirugía. Se mantuvo un régimen dietético adecuado para conservar estable el peso corporal de los perros.
Las concentraciones de APPs aumentaron significativamente en los días 2–3 para la CRP y en los días 2–7 para la Hp y la Cp. En los días 3–4 tras la castración, los niveles de adiponectina fueron significativamente inferiores a los previos a la cirugía (p < 0,05 y < 0,01, respectivamente). Tras este cambio inicial, la adiponectina no mostró alteraciones significativas durante los 3 meses posteriores.
Las concentraciones séricas de IGF-1 disminuyeron significativamente en los días 2–5 después de la castración. Además, en las semanas 8 y 12 los niveles séricos de IGF-1 fueron significativamente menores (p < 0,001 y < 0,01 respectivamente) en comparación con los valores previos a la cirugía.
En conclusión, la orquiectomía indujo un proceso inflamatorio a corto plazo que se asoció con un aumento de los niveles séricos de APPs y una disminución de los niveles de IGF-1 y adiponectina. Sin embargo, la orquiectomía no produjo cambios a largo plazo en las concentraciones circulantes de APPs ni de adiponectina. Aunque se registró una disminución de los niveles de IGF-1 dos meses después de la cirugía, posiblemente como consecuencia de la reducción asociada de los niveles de andrógenos o de la restricción alimentaria.
The objective of this study was to evaluate the possible effects of orchidectomy and associate hormonal changes on circulating concentrations of acute-phase proteins (APPs) (CRP – C-reactive protein; Hp – haptoglobin; Cp – ceruloplasmin), adiponectin and IGF-1 in dogs. For this, a total of five adult Beagle dogs were subjected to orchidectomy. Blood samples were taken before neutering, during six consecutive days and on weeks 2, 4, 8 and 12 after surgery. Appropriate diet regime was maintained to keep stable body weight of the dogs. Concentrations of APPs significantly increased on days 2–3 for CRP and 2–7 for Hp and Cp. On days 3–4 after neutering, adiponectin levels were significantly lower than before surgery (p < 0.05 and <0.01, respectively). After this initial change, adiponectin did not show any significant alteration during the 3 months. Serum IGF-1 concentrations were significantly decreased at days 2–5 after neutering. In addition, on weeks 8 and 12 serum IGF-1 levels were significantly lower (p < 0.001 and <0.01 respectively) in comparison with those before surgery. In conclusion, orchidectomy induced a short-term inflammatory process that was associated with the increase in serum levels of APPs and decrease in IGF-1 and adiponectin levels. However, orchidectomy did not result in long-term changes of circulating concentrations of APPs or adiponectin. Although a decrease in IGF-1 levels was recorded 2 months after surgery, possibly as a consequence of associated decrease in androgen levels or food restriction.
The objective of this study was to evaluate the possible effects of orchidectomy and associate hormonal changes on circulating concentrations of acute-phase proteins (APPs) (CRP – C-reactive protein; Hp – haptoglobin; Cp – ceruloplasmin), adiponectin and IGF-1 in dogs. For this, a total of five adult Beagle dogs were subjected to orchidectomy. Blood samples were taken before neutering, during six consecutive days and on weeks 2, 4, 8 and 12 after surgery. Appropriate diet regime was maintained to keep stable body weight of the dogs. Concentrations of APPs significantly increased on days 2–3 for CRP and 2–7 for Hp and Cp. On days 3–4 after neutering, adiponectin levels were significantly lower than before surgery (p < 0.05 and <0.01, respectively). After this initial change, adiponectin did not show any significant alteration during the 3 months. Serum IGF-1 concentrations were significantly decreased at days 2–5 after neutering. In addition, on weeks 8 and 12 serum IGF-1 levels were significantly lower (p < 0.001 and <0.01 respectively) in comparison with those before surgery. In conclusion, orchidectomy induced a short-term inflammatory process that was associated with the increase in serum levels of APPs and decrease in IGF-1 and adiponectin levels. However, orchidectomy did not result in long-term changes of circulating concentrations of APPs or adiponectin. Although a decrease in IGF-1 levels was recorded 2 months after surgery, possibly as a consequence of associated decrease in androgen levels or food restriction.
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Citation
Reproduction in Domestic Animals 46, 957–963 (2011)
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