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The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis – a pilot study using a Syrian hamster model

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dc.contributor.authorMolina Prats, Patricia
dc.contributor.authorGómez García, Francisco
dc.contributor.authorMartínez Díaz, Francisco
dc.contributor.authorAmaral Mendes, Rui
dc.contributor.authorLópez Jornet, María Pia
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-12-12T12:20:09Z
dc.date.available2024-12-12T12:20:09Z
dc.date.issued2016-07-05
dc.description© 2016 John Wiley & Son. This document is the Published version of a Published Work that appeared in final form in Journal of Oral Pathology & Medicine. To access the final edited and published work see https://doi.org/10.1111/jop.12473
dc.description.abstractObjective: Oral mucositis (OM) is a common complication of chemotherapy and radiotherapy. The aim of this study was to evaluate the effects of treating 5-fluorouracil-induced OM with apigenin and dexamethasone. Methods: Thirty-six male Syrian hamsters were randomly assigned to one of three groups: control (50% acetic acid + 5-FU), 50% acetic acid + 5-FU + potassium Apigenin (KA), and 50% acetic acid + 5-FU + dexamethasone. The animals from each group were sacrificed 5, 7, 10, and 14 days after inducing the mucositis, and two samples collected from each animal, accounting a total of 72 samples. Macroscopic changes were assessed by histomorphometric analysis, with ulcers being assessed by imaging analysis and the number of inflammatory cells in the ulcerated region quantified in all periods through histomorphometric analysis (H&E). Furthermore, immunohistochemical changes were evaluated by proliferating cell nuclear antigen. Results: All groups presented an increased inflammatory infiltrate after 7 days, compared to other evaluation times (P ≥ 0.05). There was significant difference between apigenin and control group in the 10-days period. Lower quantity of inflammatory cells in the apigenin-treated group in comparison with control group in the 7- and 10-days periods was observed (P < 0.05). No statistically significant difference was verified among the groups in 5- and 14-days periods. The healing process of the control group was slower than that of apigenin and dexamethasone-treated groups, with an overall significant difference between apigenin and the control group in the 10-days period. Conclusions: Apigenin treatment may enhance healing of OM induced by 5-fluorouracil, thus suggesting that more extensive research in this area may be useful to assess the role of agents of natural origin capable of preventing OM. Hence, further studies involving broader samples are need to confirm the therapeutic potential shown by this study.es
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dc.identifier.citationJ Oral Pathol Med (2017) 46: 142–147
dc.identifier.doihttps://doi.org/10.1111/jop.12473
dc.identifier.issnPrint: 1600-0714
dc.identifier.issnElectronic: 0904-2512
dc.identifier.urihttp://hdl.handle.net/10201/147391
dc.languageenges
dc.publisherWiley
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/jop.12473
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectApigenines
dc.subjectDexamethasonees
dc.subjectOral mucositises
dc.subjectSyrian golden hamsteres
dc.titleThe therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis – a pilot study using a Syrian hamster modeles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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