Publication:
Infective endocarditis in children and adolescents: a different profile with clinical implications

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dc.contributor.authorVicent, Lourdes
dc.contributor.authorGoenaga, Miguel Ángel
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorMarín-Arriaza, Mercedes
dc.contributor.authorValerio, Maricela
dc.contributor.authorFariñas, M. Carmen
dc.contributor.authorCobo-Belaustegui, Manuel
dc.contributor.authorAlarcón, Arístides de
dc.contributor.authorRodríguez-Esteban, M. Ángeles
dc.contributor.authorMiró, J. M.
dc.contributor.authorGoikoetxea-Agirre, Ane Josune
dc.contributor.authorCastro Campos, Daniel de
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.authorMartínez-Sellés, Manuel
dc.contributor.authorGAMEs investigators
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-26T08:00:03Z
dc.date.available2024-06-26T08:00:03Z
dc.date.issued2022-02-11
dc.description©2022 The author(s), under exclusive licence to the International Pediatric Research Foundation. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Pediatric Research . To access the final edited and published work see https://doi.org/10.1038/s41390-022-01959-3es
dc.description.abstractBACKGROUND: Our aim was to compare pediatric infective endocarditis (IE) with the clinical profile and outcomes of IE in adults. METHODS: Prospective multicenter registry in 31 Spanish hospitals including all patients with a diagnosis of IE from 2008 to 2020. RESULTS: A total of 5590 patients were included, 49 were <18 years (0.1%). Congenital heart disease (CHD) was present in 31children and adolescents (63.2%). Right-sided location was more common in children/adolescents than in adults (46.9% vs. 6.3%, P < 0.001). Pediatric pulmonary IE was more frequent in patients with CHD (48.4%) than in those without (5.6%), P = 0.004.Staphylococcus aureus etiology tended to be more common in pediatric patients (32.7%) than in adults (22.3%), P = 0.082. Heart failure was less common in pediatric patients than in adults, due to the lower rate of heart failure in children/adolescents with CHD (9.6%) with respect to those without CHD (44.4%), P = 0.005. Inhospital mortality was high in both children, and adolescents and adults (16.3% vs. 25.9%; P = 0.126). CONCLUSIONS: Most IE cases in children and adolescents are seen in patients with CHD that have a more common right-sided location and a lower prevalence of heart failure than patients without CHD. IE in children and adolescents without CHD has a more similar profile to IE in adults.es
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dc.identifier.citationPediatric Research (2022) 92(5): 1400–1406
dc.identifier.doihttps://doi.org/10.1038/s41390-022-01959-3
dc.identifier.issnPrint: 0031-3998
dc.identifier.issnElectronic: 1530-0447
dc.identifier.urihttp://hdl.handle.net/10201/142679
dc.languageenges
dc.publisherSpringer Naturees
dc.relationSin financiación externa a la Universidad. [Lourdes Vicent recibe financiación del Instituto de Salud Carlos III, España (CM20/00104), pero ésta es ajena a este estudio]es
dc.relation.publisherversionhttps://www.nature.com/articles/s41390-022-01959-3es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleInfective endocarditis in children and adolescents: a different profile with clinical implicationses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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