Publication: Infective endocarditis in children and adolescents: a different profile with clinical implications
Authors
Vicent, Lourdes ; Goenaga, Miguel Ángel ; Muñoz, Patricia ; Marín-Arriaza, Mercedes ; Valerio, Maricela ; Fariñas, M. Carmen ; Cobo-Belaustegui, Manuel ; Alarcón, Arístides de ; Rodríguez-Esteban, M. Ángeles ; Miró, J. M. ; Goikoetxea-Agirre, Ane Josune ; Castro Campos, Daniel de ; García-Vázquez, Elisa ; Martínez-Sellés, Manuel ; GAMEs investigators
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Publisher
Springer Nature
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DOI
https://doi.org/10.1038/s41390-022-01959-3
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info:eu-repo/semantics/article
Description
©2022 The author(s), under exclusive licence to the International Pediatric Research Foundation. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Accepted, version of a Published Work that appeared in final form in Pediatric Research . To access the final edited and published work see https://doi.org/10.1038/s41390-022-01959-3
Abstract
BACKGROUND: Our aim was to compare pediatric infective endocarditis (IE) with the clinical profile and outcomes of IE in adults.
METHODS: Prospective multicenter registry in 31 Spanish hospitals including all patients with a diagnosis of IE from 2008 to 2020.
RESULTS: A total of 5590 patients were included, 49 were <18 years (0.1%). Congenital heart disease (CHD) was present in 31children and adolescents (63.2%). Right-sided location was more common in children/adolescents than in adults (46.9% vs. 6.3%, P < 0.001). Pediatric pulmonary IE was more frequent in patients with CHD (48.4%) than in those without (5.6%), P = 0.004.Staphylococcus aureus etiology tended to be more common in pediatric patients (32.7%) than in adults (22.3%), P = 0.082. Heart failure was less common in pediatric patients than in adults, due to the lower rate of heart failure in children/adolescents with CHD (9.6%) with respect to those without CHD (44.4%), P = 0.005. Inhospital mortality was high in both children, and adolescents and adults (16.3% vs. 25.9%; P = 0.126).
CONCLUSIONS: Most IE cases in children and adolescents are seen in patients with CHD that have a more common right-sided location and a lower prevalence of heart failure than patients without CHD. IE in children and adolescents without CHD has a more similar profile to IE in adults.
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Citation
Pediatric Research (2022) 92(5): 1400–1406
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