Publication:
The regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosis

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dc.contributor.authorHang, Peng-zhou
dc.contributor.authorGe, Feng-qin
dc.contributor.authorLi, Pei-feng
dc.contributor.authorLiu, Jie
dc.contributor.authorZhu, Hua
dc.contributor.authorZhao, Jing
dc.date.accessioned2023-01-31T09:58:36Z
dc.date.available2023-01-31T09:58:36Z
dc.date.issued2021
dc.description.abstractFibrosis across diverse organ systems is one of the leading causes of morbidity and mortality by inducing progressive architectural remodeling and organ dysfunction. Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptor B (TrkB) play crucial roles in regulating neural survival, development, function and plasticity in the central and the peripheral nervous system. Previous studies demonstrated that the BDNF/TrkB pathway is widely distributed in different cell types such as neuron, epithelial cell, hepatocyte, and cardiomyocyte. Recently, there is increasing recognition that BDNF and TrkB are also expressed in fibroblasts in different organs. Moreover, growing evidence was obtained regarding the functional roles of BDNF/TrkB signaling in organ and tissue fibrosis. Thus, this review summarizes the basic molecular characteristics of the BDNF/TrkB cascade and the findings of the crucial roles and therapeutic value in organ and tissue fibrosis including pulmonary fibrosis, hepatic fibrosis, renal fibrosis, cardiac fibrosis, bladder fibrosis and skin fibrosis. Small molecule BDNF mimetic and BDNFrelated non-coding RNAs are also discussed for developing new therapeutic approaches for fibrotic disorders.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology Vol. 36, nº11 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-368
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127985
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBDNF/TrkBes
dc.subjectNoncoding RNAes
dc.subjectOrgan fibrosises
dc.subjectTissue fibrosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº11 (2021)