Publication: The regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosis
Authors
Hang, Peng-zhou ; Ge, Feng-qin ; Li, Pei-feng ; Liu, Jie ; Zhu, Hua ; Zhao, Jing
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-368
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Fibrosis across diverse organ systems is one
of the leading causes of morbidity and mortality by
inducing progressive architectural remodeling and organ
dysfunction. Brain-derived neurotrophic factor (BDNF)
and its receptor tyrosine kinase receptor B (TrkB) play
crucial roles in regulating neural survival, development,
function and plasticity in the central and the peripheral
nervous system. Previous studies demonstrated that the
BDNF/TrkB pathway is widely distributed in different
cell types such as neuron, epithelial cell, hepatocyte, and
cardiomyocyte. Recently, there is increasing recognition
that BDNF and TrkB are also expressed in fibroblasts in
different organs. Moreover, growing evidence was
obtained regarding the functional roles of BDNF/TrkB
signaling in organ and tissue fibrosis. Thus, this review
summarizes the basic molecular characteristics of the
BDNF/TrkB cascade and the findings of the crucial roles
and therapeutic value in organ and tissue fibrosis
including pulmonary fibrosis, hepatic fibrosis, renal
fibrosis, cardiac fibrosis, bladder fibrosis and skin
fibrosis. Small molecule BDNF mimetic and BDNFrelated non-coding RNAs are also discussed for
developing new therapeutic approaches for fibrotic
disorders.
publication.page.subject
Citation
Histology and Histopathology Vol. 36, nº11 (2021)
item.page.embargo
Ir a EstadÃsticas
Este Ãtem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/