Publication: lmmunohistochemical study of intracranial cysts
Authors
Coca, S. ; Martínez, A. ; Vaquero, J. ; Moreno M. ; Martos, J.A. ; Rodríguez, J. ; Mata, P.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
We present the irnmunohistochernical study
of 11 cases of intracranial cysts: two extraventricular
ependymal cysts, three colloid cysts of the third
ventricle, four extraventricular choroidal cysts and two
Rathke's cleft cysts. Antibodies against glial fibrillary
acidic protein (GFAP), cytokeratins (AE1, CKSD, AE3),
S-100 protein, epithelial membrane antigen (EMA),
vimentin, neuron specific enolase (NSE), neurofilaments
protein (NF) and prealbumin, were used. The epithelium
of choroidal cysts, showed strong immunoreactivity for
Prealbumin and cytokeratins, similar to the normal
choroid plexus epithelium. The ependymal cysts showed
epithelial immunoreactivity for GFAP and S-100, both
glial markers expressed by the normal ependymal
epithelium. On the contrary, the epithelial wall of colloid
cysts and Rathke's cleft cyst, expressed epithelial
markers (cytokeratins and EMA) but no neuroepithelial
markers, with a immuno-phenotype similar to that of
other cysts of endodermal nature. This finding supports
the neuroepithelial origin for choroid and ependymal
cysts, and an endodermal nature for colloid and Rathke's
cleft cysts. We conclude that these immunohistochernical
markers are useful in the differential diagnosis of
intracranial cysts
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.