Publication: The role of dendritic cells in immune regulation of nasal polyps
Authors
Liang, Zhuoping ; Yang, Ting ; Xu, Wei ; Huang, Ying ; Jiang, Liang ; Yin, Zedeng ; Qin, Gang
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI:10.4670/HH-11-773
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Nasal polyps (NPs) are caused by a variety
of immune cells and inflammatory cells. However, as the
most potent antigen-presenting cells in the immune
system, the role of dendritic cells (DCs) in NPs is still
unclear. In the present research, we studied the role of
DCs in immune regulation of NPs. Thirty patients with
NPs, who served as the experimental group, received
systemic and local glucocorticoids for 4-7 d, and
specimens were collected prior to hormone treatment
and during surgery. Normal middle turbinate mucosa
tissues from 18 patients who underwent nasal septum
surgery were collected as controls. The expression levels
of CD83, tumor necrosis factor-α (TNF-α), interleukin-4
(IL-4) and eosinophils (EOS) in NP tissues before and
after glucocorticoid therapy and in control middle
turbinate mucosa tissues were studied. After
glucocorticoid therapy, the expression levels of CD83,
TNF-α, IL-4 and EOS decreased significantly. In
addition, the expression of IL-4 was lower than that of
TNF-α, reversing the Th2 cytokine-dominant condition.
CD83 and EOS showed a positive correlation. DCs
participated in the development and progression of NPs
and could promote the generation of Th2 cytokines.
After interference by glucocorticoid therapy, DCs could
inhibit the expression of Th2 cytokines and induce
secretion of Th1 cytokines. DCs and EOS thus might
both play roles in promoting the development and
progression of NPs, but the underlying mechanism
requires further study.
publication.page.subject
Citation
Histology and Histopathology, Vol.32, nº1, (2017)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/