Publication: A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019
Authors
Zhou, Hang ; Liu, Li-Ping ; Fang, Mei ; Li, Yu-Mei ; Zheng, Yun-Wen
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-223
1699-5848
1699-5848
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The novel coronavirus disease 2019
(COVID-19) outbreak began in the city of Wuhan,
whereupon it rapidly spread throughout China and
subsequently across the world. Rapid transmission of
COVID-19 has caused wide-spread panic. Many
established medications have been used to treat the
disease symptoms; however, no specific drugs or
vaccines have been developed. Organoids derived from
human induced pluripotent stem cells (iPSCs) may serve
as suitable infection models for ex vivo mimicking of the
viral life cycle and drug screening. Human iPSC-3D
organoids, self-organised tissues with multiple cell
environments, have a similar structure and function as
real human organs; hence, these organoids allow greater
viral infection efficiency, mimic the natural host-virus
interactions, and are suitable for long-term
experimentation. Here, we suggest the use of a
functional human iPSC-organoid that could act as a
reliable and feasible ex vivo infection model for
investigation of the virus. This approach will provide
much needed insight into the underlying molecular
dynamics of COVID-19 for the development of novel
treatment and prevention strategies
publication.page.subject
Citation
Histology and Histopathology Vol. 35, nº10 (2020)
item.page.embargo
Ir a EstadÃsticas
Este Ãtem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/