Publication: Role of Müller glia in neuroprotection
and regeneration in the retina
Authors
García, M. ; Vecino, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Glial cells are thought to protect neurons
from various neurological insults. When there is injury
to retina, Müller cells, which are the predominant glial
element in the retina, undergo significant morphological,
cellular and molecular changes. Some of these changes
reflect Müller cell involvement in protecting the retina
from further damage. Müller cells express growth
factors, neurotransmitter transporters and antioxidant
agents that could have an important role in preventing
excitotoxic damage to retinal neurons. Moreover, Müller
cells contact to endothelial cells to facilitate the
neovascularization process during hypoxic conditions.
Finally, recent studies have pointed to a role of Müller
cells in retina regeneration after damage,
dedifferentiating to progenitor cells and then giving rise
to different neuronal cell types. In this article we will
review the role of Müller glia in neuroprotection and
regeneration after damage in the retina.
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Citation
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