Publication: Effects of sex steroids on the Syrian hamster liver
Authors
Karkare, S. ; Adamiec-Beyga, E. ; Gilloteaux, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The primary objective of this research
project was to study the role of sex steroids in the
pathogenesis of cholelithiasis using the Syrian hamster
as a model. In addition to the morphological
examination of the gallbladder epithelium, we thought it
imperative to observe the changes induced in the biliary
tract in response to the sex steroid treatment. This report
focuses on the morphological changes induced in the
liver. The hamsters were randomly divided into 4
groups, control (C), estrogen-treated (E), estrogen and
medroxyprogesterone-treated (E+MP), and medroxyprogesterone-
treated (MP) groups. The E group
hepatocytes demonstrated proliferation of the smooth
endoplasmic reticulum, lipofuscin-like granules,
aggregates of glycogen rosettes, and dense bodies. Lipid
droplets in the hepatocyte cytoplasm as well as the
nuclei were detected in this group. E+MP combined
treatment induced an exacerbation of al1 the changes
observed in the E group, furthermore, there appeared to
be a disruption of the hepatic parenchymal architecture.
The MP-treated group also exhibited the architectural
changes observed in the E+MP group, but also showed
sinusoidal dilation. In response to MP alone, the fatty
changes in the liver appeared to be accentuated. A
striking feature induced in response to MP treatment,
was a focal area suggestive of adenomatous changes.
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