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Morphological properties of human thyroid tumor cells in collagen gel culture and metastatic or invasive ability

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dc.contributor.authorNishida, S.es
dc.contributor.authorHosokawa, K.es
dc.contributor.authorKusunoki, T.
dc.contributor.authorKoezuka, M.
dc.contributor.authorAkai, F.
dc.contributor.authorNakano, T.
dc.contributor.authorFunasaka, K.
dc.contributor.authoryoshioka, Y.
dc.contributor.authorMurata, K.
dc.contributor.authorHashimoto, S.
dc.contributor.authorTomura, T.T.
dc.date.accessioned2011-02-01T09:16:38Z
dc.date.available2011-02-01T09:16:38Z
dc.date.issued1993
dc.description.abstractUsing normal human thyroid cells and tumor cells, the reconstruction of various diseased cells in collagen gel as well as the relationship between the morphology of colonies in collagen-embedded culture and the biological behavior (benignity, malignancy, metastasis, and invasion) of the original tumors were studied. In collagen gel culture, normal thyroid cells reorganized follicle-like constructions, and follicular adenoma cells showed in vivo-like constructions. However, two different types of colonies were observed in cultures of cells from papillary carcinomas. One was the branching type with many outgrowths projecting to three dimensions and the other was the spherical type without any outgrowths. These spherical colonies were observed in al1 cases of papillary carcinoma, but varied from one case to another. Metastasis and invasion were detected during pathological examination in cases with a high ratio of spherical colonies. Our results indicate that cells from highly metastatic and invasive thyroid cancer form spherical colonies in the collagen gel culture, and that this collagen culture is a useful method for studying the heterogeneity of tumor cells as well as the metastasis and invasive ability of tumor cells in vitro.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18412
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMetastasises
dc.subjectThyroid canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMorphological properties of human thyroid tumor cells in collagen gel culture and metastatic or invasive abilityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 2 (1993)