Publication: Ultrastructural evaluation of the effect of endosulfan on mice kidney
Authors
Çaglar, Y. ; Kaya, M. ; Belge, E. ; Mete, U.O.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this study, the effect of the endosulfan on
mice kidney was investigated at ultrastructural level.
Moreover, biochemical analyses (G6PD, CAT, SOD,
GSH and MDA) were determined in supernatant of
kidney tissue. Endosulfan (13mg/kg/day body weight)
was administered orally to mices via intragastric-during
10 days. The presence of mitochondrial degeneration in
cytoplasm of proximal convoluted tubule cells were a
striking feature. Furthermore, there was lipofuscin
granules and membranous structures in some of
proximal convoluted tubule cells. In some glomeruli,
ultrastructural changes such as fusion in pedicels and
focal thickening at glomerular basal membrane were
seen. There were cytoplasmic bulges in some distal
convoluted tubule cells. The biochemical results of the
experimental group were significant when compared to
the control. The effect of the endosulfan was mainly on
the proximal convoluted tubule cells. Morever, the other
parts of the nephron were effected. Thus, this
degeneration in kidney may be thought that oxidative
stress may play a role to the mediator in changing
configuration of cell membrane and seem to account for
the morphologic alteration of kidney.
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