Publication: The amniotic membrane as a source of stem cells
Authors
Insausti, Carmen L. ; Blanquer Blanquer, Miguel ; Bleda, Patricia ; Iniesta, Paqui ; Majado Martínez, Mª Juliana ; Castellanos Escrig, Gregorio ; Moraleda Jiménez, José María
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Cellular therapy has emerged as a new
potential tool for curing a wide range of degenerative
diseases and tissue necrosis. Embryonic stem cells
possess potential for differentiation into a wide range of
cell lineages, but the ethical issues associated with
establishment of this human cell line have to be resolved
prior to any use. The bone marrow (BM) is the usual
source of adult stem cells for hematopoietic stem cell
transplants and cellular therapy, but the BM harvest is a
surgical procedure that requires general anesthesia or
sedation, and there seems to be a reduction of the
proliferative potential and differentiation capacity of the
marrow mesenchymal stem cells in older donors. For
these reasons there is an increasing interest in other
sources of stem cells from adult and fetal tissues. The
amniotic membrane (AM) or amnion is a tissue of
particular interest because its cells possess
characteristics of stem cells with multipotent
differentiation ability, and because of low
immunogenicity and easy procurement from the
placenta, which is a discarded tissue after parturition,
thus avoiding the current controversies associated with
the use of human embryonic stem cells. Therefore,
amniotic membrane has been proposed as a good
candidate to be used in cellular therapy and regenerative
medicine.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.