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Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system

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dc.contributor.authorDanguy, A.es
dc.contributor.authorRorive, S.es
dc.contributor.authorDecaestecker, C.
dc.contributor.authorBronckart, Y.
dc.contributor.authorKaltner, H.
dc.contributor.authorHadari, Y.R.
dc.contributor.authorGoren, R.
dc.contributor.authorZich, Y.
dc.contributor.authorPetein, M.
dc.contributor.authorSalmon, I.
dc.contributor.authorGabius, H.J.
dc.contributor.authorKiss, R.
dc.date.accessioned2011-05-11T10:56:29Z
dc.date.available2011-05-11T10:56:29Z
dc.date.issued2001
dc.description.abstractThis study aims to investigate whether the immunohistochemical expression of galectin-8 could be used as a diagnostic marker in tumor tissues of various histogenetic origins including specimens from epithelial (n=145), mesenchymatous (n=16), adipous (n=10) and central and peripheral nervous system (n=25) tissue, and 4 mesotheliomas. Immunohistochemical reactions were carried out with a polyclonal anti-galectin-8 antibody and histological slides from tissues derived from the files of the Laboratory of Anatomopathology of University Erasmus Hospital, Brussels. Formalin-fixed paraffinembedded tissues of 45 normal cases as well as 41 benign and 114 malignant tumors were studied. Marked decreases in immunohistochemical galectin-8 expression were obsewed in colon (p=0.001), pancreas (p=0.007), liver (p=0.0008), skin (p=0.002) and larynx (p=0.02) tissue when comparing malignant tissue to normal tissue andlor benign tumors. The reverse relationship was observed for breast tissue (p=0.007). No statistically significant differences (p>0.05) were detected when comparing normal tissue andlor benign to malignant tumors in lung, bladder, kidney, prostate and stomach tissue. Significant galectin-8 expression was also measured in non-epithelial tissue including tumors of the central and peripheral nervous system as well as in skeletal muscle and mesotheliomas. Immunohistochemical monitoring of galectin-8 thus reveals an organtype- dependent regulation of expression upon malignant transformation of various tissue types of epithelial origin. This observation will prompt further studies to 0ffprin.int requests to: Roberl Kiss, Ph.D., Laboratory of Histopathology, Faculty of Medicine - Free University of Brussels, 808 route de Lennik - 1070 Brussels, Belgiurn. Fax: 322 555 62 85. e-rnail: rkiss@ulb.ac.be delineate any relationship with prognosises
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20688
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectLectinses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleImmunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous systemes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 3 (2001)