Publication: Immunohistochemical profile of
galectin-8 expression in benign and
malignant tumors of epithelial, mesenchymatous
and adipous origins, and of the nervous system
Loading...
Date
2001
Authors
Danguy, A. ; Rorive, S. ; Decaestecker, C. ; Bronckart, Y. ; Kaltner, H. ; Hadari, Y.R. ; Goren, R. ; Zich, Y. ; Petein, M. ; Salmon, I. ; Gabius, H.J. ; Kiss, R.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
This study aims to investigate whether the
immunohistochemical expression of galectin-8 could be
used as a diagnostic marker in tumor tissues of various
histogenetic origins including specimens from epithelial
(n=145), mesenchymatous (n=16), adipous (n=10) and
central and peripheral nervous system (n=25) tissue, and
4 mesotheliomas. Immunohistochemical reactions were
carried out with a polyclonal anti-galectin-8 antibody
and histological slides from tissues derived from the files
of the Laboratory of Anatomopathology of University
Erasmus Hospital, Brussels. Formalin-fixed paraffinembedded
tissues of 45 normal cases as well as 41
benign and 114 malignant tumors were studied. Marked
decreases in immunohistochemical galectin-8 expression
were obsewed in colon (p=0.001), pancreas (p=0.007),
liver (p=0.0008), skin (p=0.002) and larynx (p=0.02)
tissue when comparing malignant tissue to normal tissue
andlor benign tumors. The reverse relationship was
observed for breast tissue (p=0.007). No statistically
significant differences (p>0.05) were detected when
comparing normal tissue andlor benign to malignant
tumors in lung, bladder, kidney, prostate and stomach
tissue. Significant galectin-8 expression was also
measured in non-epithelial tissue including tumors of the
central and peripheral nervous system as well as in
skeletal muscle and mesotheliomas. Immunohistochemical
monitoring of galectin-8 thus reveals an organtype-
dependent regulation of expression upon malignant
transformation of various tissue types of epithelial
origin. This observation will prompt further studies to
0ffprin.int requests to: Roberl Kiss, Ph.D., Laboratory of Histopathology,
Faculty of Medicine - Free University of Brussels, 808 route de Lennik -
1070 Brussels, Belgiurn. Fax: 322 555 62 85. e-rnail: rkiss@ulb.ac.be
delineate any relationship with prognosis
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.