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Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients

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dc.contributor.authorMousa, Shaaban A.
dc.contributor.authorKrajnik, Malgorzata
dc.contributor.authorSobanski, Piotr
dc.contributor.authorKowalewski, Janusz
dc.contributor.authorBloch-Boguslawska, Elzbieta
dc.contributor.authorZylicz, Zbigniew
dc.contributor.authorSchafer, Michael
dc.date.accessioned2015-10-06T14:49:29Z
dc.date.available2015-10-06T14:49:29Z
dc.date.issued2010
dc.description.abstractFunctional evidence suggests that opioid peptides such as dynorphin are involved in the regulation of airway macrophage functions and of human cancer growth. However, anatomical evidence for components of a putative dynorphin network within lung cancer patients is scarce. Tissue from lung cancer patients was examined immunohistochemically for all components of a local dynorphin (DYN) network. Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients. Moreover, chromograninAimmunoreactive pulmonary neuroendocrine cells expressing DYN were close to substance P- and KORimmunoreactive sensory nerves. Our findings give a first hint of a neuroanatomical basis for a peripheral DYN network, conceivably regulating pulmonary, immune and cell-proliferative functions within the human lung, most likely in a paracrine/autocrine fashion.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/46510
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 25, nº 6 (2010)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOpioid peptideses
dc.subjectCarboxypeptidasees
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleDynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patientses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº6 (2010)