Publication: Dynorphin expression, processing and
receptors in the alveolar macrophages, cancer cells
and bronchial epithelium of lung cancer patients
Authors
Mousa, Shaaban A. ; Krajnik, Malgorzata ; Sobanski, Piotr ; Kowalewski, Janusz ; Bloch-Boguslawska, Elzbieta ; Zylicz, Zbigniew ; Schafer, Michael
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Functional evidence suggests that opioid
peptides such as dynorphin are involved in the regulation
of airway macrophage functions and of human cancer
growth. However, anatomical evidence for components
of a putative dynorphin network within lung cancer
patients is scarce. Tissue from lung cancer patients was
examined immunohistochemically for all components of
a local dynorphin (DYN) network. Double
immunofluorescence microscopy analysis revealed
colocalization of the opioid precursor PDYN with its
end-product DYN, and key processing enzymes
prohormone convertases 1 and 2 and carboxypeptidase
E, as well as the kappa-opioid receptor (KOR) within
alveolar macrophages and cancerous cells in varying
degrees among patients. Moreover, chromograninAimmunoreactive
pulmonary neuroendocrine cells
expressing DYN were close to substance P- and KORimmunoreactive
sensory nerves. Our findings give a first
hint of a neuroanatomical basis for a peripheral DYN
network, conceivably regulating pulmonary, immune
and cell-proliferative functions within the human lung,
most likely in a paracrine/autocrine fashion.
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