Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance

Publication:
Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance

dc.contributor.author	Madrenas, J.	es
dc.contributor.author	Lazarovits, A.I.	es
dc.date.accessioned	2011-02-22T10:57:59Z
dc.date.available	2011-02-22T10:57:59Z
dc.date.issued	1998
dc.description.abstract	Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here. we summarize the evidence supporting a critical role for the CO-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/19027
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Transplantation	es
dc.subject	T cell tolerance	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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