Publication:
Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance

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Differential signaling through the T cell receptor from biochemistry....pdf(6.08 MB)
Date
1998
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Authors
Madrenas, J. ; Lazarovits, A.I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here. we summarize the evidence supporting a critical role for the CO-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.
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Transplantation , T cell tolerance
Citation
URI
http://hdl.handle.net/10201/19027
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Histology and histopathology Vol.13, nº 1 (1998)
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