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The application of stem cells in the treatment of ischemic diseases

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dc.contributor.authorChen, C.P.es
dc.contributor.authorLee, Y.J.es
dc.contributor.authorChiu, S.T.
dc.contributor.authorShyu, W.C.
dc.contributor.authorLee, M.Y.
dc.contributor.authorHuang, S.P.
dc.contributor.authorLi, H.
dc.date.accessioned2011-06-30T12:01:43Z
dc.date.available2011-06-30T12:01:43Z
dc.date.issued2006
dc.description.abstractIschemia causes oxygen deprivation, cell injury and related organ dysfunction. Although ischemic injury may be local, it involves many biochemical changes in different cell types. The ability of stem cells to differentiate into different cell lineages provides the possibility of their use in treating a variety of diseases requiring tissue repair or reconstitution, such as stroke, ischemic retinopathy, myocardial infarction, ischemic disorders of the liver, ischemic renal failure, and ischemic limb dysfunction. Several cell types including embryonic stem cells, various progenitor and stem cells of hematopoietic or mesenchymal origin have been used in attempts to reconstitute injured tissue. Xenologous or autologous stem cells may be administered either through the peripheral vascular system or directly by regional injection. The stem cells are then guided to the infarct site by homing signals. Either by cell differentiation or paracrine effects, stem cells or progenitor cells participate in the reconstruction of a favorable microenvironment resulting in neovascularization and tissue regeneration that eventually improve the physiological function of organs with ischemic damage.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22586
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectStem celles
dc.subjectIschemic diseaseses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe application of stem cells in the treatment of ischemic diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº11 (2006)