Publication: The application of stem cells in the treatment of ischemic diseases
Loading...
Date
2006
Authors
Chen, C.P. ; Lee, Y.J. ; Chiu, S.T. ; Shyu, W.C. ; Lee, M.Y. ; Huang, S.P. ; Li, H.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Ischemia causes oxygen deprivation, cell
injury and related organ dysfunction. Although ischemic
injury may be local, it involves many biochemical
changes in different cell types. The ability of stem cells
to differentiate into different cell lineages provides the
possibility of their use in treating a variety of diseases
requiring tissue repair or reconstitution, such as stroke,
ischemic retinopathy, myocardial infarction, ischemic
disorders of the liver, ischemic renal failure, and
ischemic limb dysfunction. Several cell types including
embryonic stem cells, various progenitor and stem cells
of hematopoietic or mesenchymal origin have been used
in attempts to reconstitute injured tissue. Xenologous or
autologous stem cells may be administered either
through the peripheral vascular system or directly by
regional injection. The stem cells are then guided to the
infarct site by homing signals. Either by cell
differentiation or paracrine effects, stem cells or
progenitor cells participate in the reconstruction of a
favorable microenvironment resulting in
neovascularization and tissue regeneration that
eventually improve the physiological function of organs
with ischemic damage.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.