Publication: MicroRNA and ovarian cancer
Authors
Corney, David C. ; Nikitin, Alexander Yu.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ovarian cancer remains a leading cause of
morbidity and mortality, with little change in survival
rates over the past 30 years. Research in the molecular
biology underlying the disease demonstrates frequent
mutation in the p53/Rb/p16 tumor suppressor pathways
and activation of c-myc, K-ras and Akt oncogenic
signaling. Recently, miRNAs have been demonstrated to
play an important role in controlling proliferation,
apoptosis and many other processes altered in the cancer
state. In this review we discuss a number of recent
publications that implicate a role for microRNAs in
ovarian cancer and assess how this new field may
improve our fundamental understanding of the disease
and provide improved diagnostic and therapeutic
approaches.
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