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BCR-ABL negative myeloproliferative neoplasia: a review of involved molecular mechanisms

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dc.contributor.authorKoopmans, Suzanne M.
dc.contributor.authorSchouten, Harry C.
dc.contributor.authorvan Mario, Ariënne M.W.
dc.date.accessioned2020-02-06T19:14:58Z
dc.date.available2020-02-06T19:14:58Z
dc.date.issued2015
dc.description.abstractThe clonal bone marrow stem cell disorders essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) belong to the group of Philadelphia chromosome negative myeloproliferative neoplasia (Ph- MPN). In 2005 the JAK2V617F mutation was discovered which has generated more insight in the pathogenetic mechanism of the MPNs. More mutations have been detected in MPN patients since. However, the underlying cause of MPN has not been discovered so far. The mechanism of increased angiogenesis in MPNs and the development of fibrosis in the bone marrow in PMF patients and in some ET and PV patients is still not known. This review will focus on the most important molecular pathogenetic mechanisms in MPN patients.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 2 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-30.151
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/86457
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMyeloproliferative neoplasiaes
dc.subjectEssential thrombocythaemiaes
dc.subjectPolycythemia veraes
dc.subjectPrimary myelofibrosises
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleBCR-ABL negative myeloproliferative neoplasia: a review of involved molecular mechanismses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº2 (2015)