Publication: BCR-ABL negative myeloproliferative neoplasia:
a review of involved molecular mechanisms
Authors
Koopmans, Suzanne M. ; Schouten, Harry C. ; van Mario, Ariënne M.W.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.151
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info:eu-repo/semantics/article
Description
Abstract
The clonal bone marrow stem cell disorders
essential thrombocythemia (ET), polycythemia vera
(PV) and primary myelofibrosis (PMF) belong to the
group of Philadelphia chromosome negative
myeloproliferative neoplasia (Ph- MPN). In 2005 the
JAK2V617F mutation was discovered which has generated
more insight in the pathogenetic mechanism of the
MPNs. More mutations have been detected in MPN
patients since. However, the underlying cause of MPN
has not been discovered so far. The mechanism of
increased angiogenesis in MPNs and the development of
fibrosis in the bone marrow in PMF patients and in some
ET and PV patients is still not known. This review will
focus on the most important molecular pathogenetic
mechanisms in MPN patients.
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Citation
Histology and Histopathology, Vol. 30, n.º 2 (2015)
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