Publication: Eosinophils and human cancer
Authors
Samoszuk, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Eosinophils are rare granulocytes that are
normally associated with allergic diseases or responses
to various parasitic infections. Many types of human
cancer, however, are also associated with extensive
eosinophilia, either within the tumor itself, or in the
peripheral blood, or in both locations. Special techniques
such as autofluorescence or immunohistochemistry are
sometimes needed to detect the presence of intact and
degranulating eosinophils within the tumors. With the
help of these techniques, extensive eosinophilia is most
often seen in hematologic tumors such as Hodgkin's
disease and certain lymphomas; however, many other
types of cancer such as colon, cervix, lung, breast, and
ovary also contain eosinophilia if diligently sought.
Although the presence or absence of eosinophilia within
these tumors does not appear to have a major influence
on the prognosis of the patient, eosinophils may play an
important role in the host interaction with the tumor,
perhaps by promoting angiogenesis and connective
tissue formation adjacent to the cancer. In addition,
tumor-related eosinophilia provides some interesting
clues into tumor biology, particularly with regard to
production of cytokines by the tumor cells.
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