Publication: A meta-analysis of gut microbiota in children with autism
Authors
Andreo Martínez, Pedro ; Rubio Aparicio, María ; Sánchez Meca, Julio ; Veas, Alejandro ; Martínez González, Agustín Ernesto
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Publisher
Springer
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DOI
https://doi.org/10.1007/s10803-021-05002-y
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info:eu-repo/semantics/article
Description
©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the accepted, version of a Published Work that appeared in final form in Journal of Autism and Developmental Disorders. To access the final edited and published work see https://doi.org/10.1007/s10803-021-05002-y
Abstract
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = − 0.999; 95% CI − 1.549, − 0.449) and Bifidobacterium genera (SMD+ = − 0.513; 95% CI − 0.953, − 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
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Citation
Journal of Autism and Developmental Disorders, 52, 2022, 1374–1387
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