Publication: Recent advances in the biology of colorectal cancer
Authors
Grogan, L. ; Behan, K.A. ; Johnston, P.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The identification of the precise molecular
defects responsible for the common forms of inherited
colorectal cancer has significantly advanced our
understanding of both inherited and sporadic disease.
These advances coupled with a rapid accumulation of
information on the molecular genotype and biological
phenotype of colorectal cancer have identified potential
markers that may prove to be not only of prognostic
value but also important as screening tools and
therapeutic targets. These molecular and biological
features include replication errors, mutations of
oncogenes and tumor suppressor genes and expression
of tumor specific antigens and cytokeratins. This review
highlights important recent advances that further our
understanding of the biology and genetics of colorectal
cancer.
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