Browsing by Subject "Oncogenes"

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    lmmunohistochemical markers of prognostic value in surgical pathology
    (Murcia : F. Hernández, 1997) Taylor, C.R.; Cote, R.J.
    Immunohistochemical methods have enjoyed rapid growth in application and utility since their initial adaptation to paraffin sections 20 years ago. Initial applications were directed primarily to the identification of cell and tumor sub-types (lineage related markers). More recently immunohistochemical markers have been described that show great promise in determining tumor prognosis, at a very early stage of tumor development, independent of stage and grade. This review surveys the recent use of immunohistochemistry in prognosis, and offers some speculation as to areas of future promise.
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    Recent advances in the biology of colorectal cancer
    (Murcia : F. Hernández, 1996) Grogan, L.; Behan, K.A.; Johnston, P.G.
    The identification of the precise molecular defects responsible for the common forms of inherited colorectal cancer has significantly advanced our understanding of both inherited and sporadic disease. These advances coupled with a rapid accumulation of information on the molecular genotype and biological phenotype of colorectal cancer have identified potential markers that may prove to be not only of prognostic value but also important as screening tools and therapeutic targets. These molecular and biological features include replication errors, mutations of oncogenes and tumor suppressor genes and expression of tumor specific antigens and cytokeratins. This review highlights important recent advances that further our understanding of the biology and genetics of colorectal cancer.