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Neuroendocrine lung structures and tumours, immunohistochemical study by specific markers

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dc.contributor.authorMosca, L.es
dc.contributor.authorBarbareschi, M.es
dc.contributor.authorMauri, M.F.
dc.contributor.authorMunguia-Barrera, J.
dc.contributor.authorFrigo, B.
dc.contributor.authorMuscara, M.
dc.contributor.authorValentini, L.
dc.contributor.authorMariscotti, C.
dc.date.accessioned2011-01-17T12:41:13Z
dc.date.available2011-01-17T12:41:13Z
dc.date.issued1988
dc.description.abstractOut of 360 lungs or lobes surgically removed, 13 non neoplastic specimens and 16 neuroendocrine (NE) tumours are investigated with immunohistochemical methods, in order to evaluate the presence of NE structures in normal and pathological human lungs. The markedused are neuron specific enolase (NSE), chromogranin (CG) and the 80 kd antigen (80 kdAg) of NE secretory granules detected by the new monoclonal Phe-5 antibody. In nonneoplastic lung specimens, clearcut immunoreactivity for al1 three markers appears in NE cells, neuroepithelial bodies (NEB), NE cell-hyperplasias and dysplasias. In the same specimens 4 tumourlets with analogous clearcut immunoreactivities were also observed. The NE tumours show distinct immunoreactivity for al1 three antisera in the 8 well differentiated cases. The 8 poorly differentiated tumours are variably immunoreactive for NSE and present low to ni1 staining with antisera to CG and 80 kdAg. The immunohistochemical data are interpreted according to current views about a possible relationship between NE tumours and parent normal NE lung structures.en_EN
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17953
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeuroendocrine cellses
dc.subjectNeuroepithelial bodieses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleNeuroendocrine lung structures and tumours, immunohistochemical study by specific markerses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 3, nº 4 (1988)