Publication: Untargeted metabolomic profiling of serum in dogs with hypothyroidism
Authors
Muñoz-Prieto, Alberto ; González-Aróstegui, Luis ; Rubic, Ivana ; Cerón, José Joaquín ; Tvarijonavicite, Asta ; Horvatic, Anita ; Mrljak, Vladimir
item.page.secondaryauthor
item.page.director
Publisher
Elsevier
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1016/j.rvsc.2021.01.023
item.page.type
info:eu-repo/semantics/article
Description
© 2021 Elsevier Ltd. All rights reserved. This document is the Published version of a Published Work that appeared in final form in Research in Veterinary Science. To access the final edited and published work see https://doi.org/10.1016/j.rvsc.2021.01.023
Abstract
Hypothyroidism is one of the most commonly diagnosed endocrine disease in dogs. The clinical signs are caused
by a deficiency of the active thyroid hormones triiodothyronine (T3) and thyroxine (T4) and have a negative
impact on dog’s quality of life. We hypothesized that serum metabolic profile varies between healthy dogs and
dogs with hypothyroidism. Twenty serum samples from dogs with hypothyroidism and 20 from healthy dogs
were used for untargeted metabolomics analysis performed by LC/MS analysis. Fifteen metabolites showed
significant changes between hypothyroid and healthy dogs, being the pentose phosphate pathway (PPP),
aminoacyl-tRNA biosynthesis and pyrimidine metabolism the principal pathways altered in hypothyroidism.
Specifically, metabolites such as D-gluconic acid and L-Isoleucine may potentially act as biomarkers of disease.
publication.page.subject
Citation
item.page.embargo
Collections
Ir a Estadísticas
Sin licencia Creative Commons.