Publication: IBL-like T cell lymphoma expressing monoclonal
gammopathy (macroglobulinemia) in the serum
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Date
1989
Authors
Kasajima, Takeshi ; Masuda, Akihiro ; Matsuda, Mikio ; Imai, Yutaka ; Tobinai, Kensei
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A case of IBL-like T cell lymphoma with
serum monoclonal gammopathy was reported. A 58-
year-old woman, who had suffered from heart failure.
was admitted because of asthma attack, fever and
lyrnphadenopathy. Leucopenia with a small amount of
atypical lymphocytes was detected. Serum analysis
showed monoclonal elevation of IgM-K (M-protein) and
hv~erviscositv. Urinarv Bence-Jones urotein was
diiected. Lymph &de biopsy rAealed the
disappearance of normal structure and proliferation of T
cells with pale cells which characterized IBL-like T cell
lymphoma. Immunocytochemistry revealed the pale
cells to bear T cell markers (MT-1, CD 5, CD 8 or CD 4)
and IgM-positive cell distribution. Tonsilar biopsy
showed the infiltration of atypical lymphoids and pale
cells. Bone marrow biopsy showed moderate
lymphoplasmacytoid proliferation with lymph follicles.
Clinical data and serum analysis suggested
macroglobulinemia. Additional lymph node biopsy was
performed and revealed IBL-like T cell lymphoma. IBLlike
T cell lymphoma is characterized by polyclonal
hypergammaglobulinemia. The present case probably
occurred initially as IBL-like T cell lymphoma and
lymphoplasmacytoid cell proliferation might have
followed due to an excess of CD 4' cells
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