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The role of the bone marrow microenvironment in multiple myeloma

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dc.contributor.authorDe Raeve, H.es
dc.contributor.authorVanderkerken, K.es
dc.date.accessioned2011-06-30T12:01:05Z
dc.date.available2011-06-30T12:01:05Z
dc.date.issued2005
dc.description.abstractMultiple myeloma (MM) is a malignant disease that results from an excess of monotypic plasma cells in the bone marrow (BM). This malignancy is characterised by complex karyotypic aberrancies. In 60% of all MM there are recurrent primary translocations involving the heavy chain gene locus. The MM cells strongly interact with the BM microenvironment, which is composed of endothelial cells, stromal cells, osteoclasts, osteoblasts, immune cells, fat cells and the extracellular matrix. This interaction is responsible for the specific homing in the BM, the proliferation and survival of the MM cells, the resistance of MM cells to chemotherapy, the development of osteolysis, immunodeficiency and anaemia. New therapeutic agents target both the MM, as well as the interaction MM cell – BM microenviroment.es
dc.formatapplication/pdfes
dc.format.extent24es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22539
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMultiple myelomaes
dc.subjectOsteoclastes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe role of the bone marrow microenvironment in multiple myelomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 4 (2005)