Publication: The role of the bone marrow microenvironment in multiple myeloma
Authors
De Raeve, H. ; Vanderkerken, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Multiple myeloma (MM) is a malignant
disease that results from an excess of monotypic plasma
cells in the bone marrow (BM). This malignancy is
characterised by complex karyotypic aberrancies. In
60% of all MM there are recurrent primary
translocations involving the heavy chain gene locus. The
MM cells strongly interact with the BM microenvironment,
which is composed of endothelial cells,
stromal cells, osteoclasts, osteoblasts, immune cells, fat
cells and the extracellular matrix. This interaction is
responsible for the specific homing in the BM, the
proliferation and survival of the MM cells, the resistance
of MM cells to chemotherapy, the development of
osteolysis, immunodeficiency and anaemia. New
therapeutic agents target both the MM, as well as the
interaction MM cell – BM microenviroment.
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Citation
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