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Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors

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dc.contributor.authorTakahiro Suzuki
dc.contributor.authorTeruyuki Sato
dc.contributor.authorKenji Izuhara
dc.contributor.authorKazue Ise
dc.contributor.authorHiroki Shimada
dc.contributor.authorKeigo Murakami
dc.contributor.authorKazuhiro Murakami
dc.contributor.authorYasuhiro Nakamura
dc.contributor.authorNobuo Ohta
dc.contributor.authorYutaka Tateda
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-05-13T09:49:23Z
dc.date.available2026-05-13T09:49:23Z
dc.date.issued2026
dc.description.abstractPeriostin is involved in airway remodeling, salivary tumors, and various otolaryngological diseases. D-β-aspartic acid is the major isomer of D-aspartic acid found in the tissues of elderly individuals. In this study, we investigated the expression and role of D-β-aspartic acid and periostin in the formation of benign parotid tumors. The data of 36 patients (16 male and 20 female) who underwent parotid tumor resection between April 2017 and March 2022 and were clinically and pathologically diagnosed as having benign parotid tumors were included in this study. The mean age of the patients was 59.2 (range 26-82) years. Tumors were histologically classified as pleomorphic adenomas, Warthin’s tumors, basal cell adenomas, oncocytomas, and myoepitheliomas. Increased D-β-aspartic acid expression was observed in the epithelium and stroma of benign parotid tumors. In the epithelium, D-β-aspartic acid was found in 35 of 38 samples (92.1%). In the stroma, it was found in 19 of 38 samples (50.0%). In the stroma of benign parotid tumors, increased expression of periostin was found in 32 of 38 samples (84.2%). Four periostin expression patterns were observed in benign parotid tumors: negative, superficial, infiltrative, and diffuse. Statistically significant differences were found between the expression pattern of D-β-aspartic acid in the stroma and the histological classification of benign parotid gland tumors. In addition, a statistically significant difference was found between the expression patterns of D-β-aspartic acid and periostin in the stroma. Our results suggest that D-β-aspartic acid and periostin may be involved in the pathogenesis of benign parotid gland tumors.
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dc.format.extent7
dc.identifier.doihttps://doi.org/10.14670/HH-25-013
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/231781
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiomarker
dc.subjectBenign parotid gland tumors, Biomarker, D β-aspartic acid, Patterns of D-β-aspartic acid expression, Periostin
dc.subjectD β-aspartic acid
dc.subjectPatterns of D-β-aspartic acid expression
dc.subjectBenign parotid gland tumors
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleImmunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº6, (2026)