Publication: Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors
Authors
Takahiro Suzuki ; Teruyuki Sato ; Kenji Izuhara ; Kazue Ise ; Hiroki Shimada ; Keigo Murakami ; Kazuhiro Murakami ; Yasuhiro Nakamura ; Nobuo Ohta ; Yutaka Tateda
item.page.secondaryauthor
item.page.director
Publisher
publication.page.editor
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.department
DOI
https://doi.org/10.14670/HH-25-013
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Periostin is involved in airway remodeling,
salivary tumors, and various otolaryngological diseases.
D-β-aspartic acid is the major isomer of D-aspartic acid
found in the tissues of elderly individuals. In this study,
we investigated the expression and role of D-β-aspartic
acid and periostin in the formation of benign parotid
tumors. The data of 36 patients (16 male and 20 female)
who underwent parotid tumor resection between April
2017 and March 2022 and were clinically and
pathologically diagnosed as having benign parotid
tumors were included in this study. The mean age of the
patients was 59.2 (range 26-82) years. Tumors were
histologically classified as pleomorphic adenomas,
Warthin’s tumors, basal cell adenomas, oncocytomas,
and myoepitheliomas. Increased D-β-aspartic acid
expression was observed in the epithelium and stroma of
benign parotid tumors. In the epithelium, D-β-aspartic
acid was found in 35 of 38 samples (92.1%). In the
stroma, it was found in 19 of 38 samples (50.0%). In the
stroma of benign parotid tumors, increased expression of
periostin was found in 32 of 38 samples (84.2%). Four
periostin expression patterns were observed in benign
parotid tumors: negative, superficial, infiltrative, and
diffuse. Statistically significant differences were found
between the expression pattern of D-β-aspartic acid in
the stroma and the histological classification of benign
parotid gland tumors. In addition, a statistically
significant difference was found between the expression
patterns of D-β-aspartic acid and periostin in the stroma.
Our results suggest that D-β-aspartic acid and periostin
may be involved in the pathogenesis of benign parotid
gland tumors.
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/