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Advances in understanding mechanisms of long-term sperm storage-the soft-shelled turtle model

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dc.contributor.authorChen, Hong
dc.contributor.authorLiu, Tengfei
dc.contributor.authorHolt, William V.
dc.contributor.authorYang, Ping
dc.contributor.authorZhang, Linli
dc.contributor.authorZhang, Li
dc.contributor.authorHan, Xiangkun
dc.contributor.authorBian, Xunguang
dc.contributor.authorChen, Qiusheng
dc.date.accessioned2022-10-28T09:21:54Z
dc.date.available2022-10-28T09:21:54Z
dc.date.issued2020
dc.description.abstractLong-term sperm storage is a special reproductive strategy, which can extend the time window between mating and fertilization in some animal species. Spermatozoa of the soft-shelled turtle, Pelodiscus sinensis, can be stored in the epididymis and oviduct for at least six months and one year, respectively. How spermatozoa can be stored in vivo for such a prolonged period is yet to be explained. We analyze the mechanisms that contribute to long-term sperm storage in P. sinensis, and compare them with other species from three different perspectives: the spermatozoon itself, the storage microenvironment and the interaction between the spermatozoon and microenvironment. Characteristics of soft-shelled turtle spermatozoa itself, such as the huge cytoplasmic droplet with its content of several large lipid droplets (LDs) and onion-like mitochondira, facilitate long-term sperm storage. The microenvironment of reproductive tract, involving in the secretions, structural barriers, exosomes, androgen receptors, Toll-like receptors and survival factor Bcl-2, are important for the maintenance of spermatozoa long-term storage. Sperm heads are always embedded among the oviductal cilia and even intercalate into the apical hollowness of the ciliated cells, indicating that the ciliated cells support the stored spermatozoa. RNA seq is firstly used to detect the molecular mechanism of sperm storage, which shows that autophagy, apoptosis and immune take part in the long-term sperm storage in this specieses
dc.formatapplication/pdfes
dc.format.extent23es
dc.identifier.citationHistology and Histopathology Vol. 35, nº 1 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-148
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/124986
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLong-term sperm storagees
dc.subjectExosomeses
dc.subjectAndrogen receptorses
dc.subjectAutophagyes
dc.subjectSoft-shelled turtlees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAdvances in understanding mechanisms of long-term sperm storage-the soft-shelled turtle modeles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº1 (2020)