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Interleukin-6: a molecule with complex biological impact in cancer

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dc.contributor.authorLacina, Lukáš
dc.contributor.authorBrábek, Jan
dc.contributor.authorKrál, Vladimír
dc.contributor.authorKodet, Ondřej
dc.contributor.authorSmetana Jr, Karel
dc.date.accessioned2022-06-08T08:13:38Z
dc.date.available2022-06-08T08:13:38Z
dc.date.issued2019
dc.description.abstractInterleukin-6 is a multifaceted cytokine, usually reported as a pro-inflammatory molecule. However, certain anti-inflammatory activities were also attributed to IL-6. The levels of IL-6 in serum as well as in other biological fluids are elevated in an agedependent manner. Notably, it is consistently reported also as a key feature of the senescence-associated secretory phenotype. In the elderly, this cytokine participates in the initiation of catabolism resulting in, e.g. sarcopenia. It can cross the blood-brain barrier, and so it is in causal association with, e.g. depression, bipolar disorder, schizophrenia, and anorexia. In the cancer patient, IL-6 is produced by cancer and stromal cells and actively participates in their crosstalk. IL-6 supports tumour growth and metastasising in terminal patients, and it significantly engages in cancer cachexia (including anorexia) and depression associated with malignancy. The pharmacological treatment impairing IL-6 signalling represents a potential mechanism of antitumour therapy targeting cancer growth, metastatic spread, metabolic deterioration and terminal cachexia in patients.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.34, nº2, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-033
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/121064
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCancer microenvironmentes
dc.subjectCytokinees
dc.subjectInterleukin-6es
dc.subjectCanceres
dc.subjectCachexiaes
dc.subjectAnorexiaes
dc.subjectDepressiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleInterleukin-6: a molecule with complex biological impact in canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nº2 (2019)