Publication: Walking metals for remote functionalization
Authors
Sommer, Heiko ; Juliá Hernández, Francisco ; Martin, Ruben ; Marek, Ilan
item.page.secondaryauthor
item.page.director
Publisher
American Chemical Society
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1021/acscentsci.8b00005
item.page.type
info:eu-repo/semantics/article
Description
© 2018 American Chemical Society. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. This document is Published, version of a Published Work that appeared in final form in ACS Central Science. To access the final edited and published work see https://doi.org/10.1021/acscentsci.8b00005
Abstract
The distant and selective activation of unreactive C−H and C−C bonds remains one of the biggest challenges in organic chemistry. In recent years, the development of remote functionalization has received growing interest as it allows for the activation of rather challenging C−H and C−C bonds
distant from the initiation point by means of a “metal-walk”. A “metal-walk” or “chain-walk” is defined by an iterative series of consecutive 1,2- or 1,3-hydride shifts of a metal complex along a single hydrocarbon chain. With this approach, simple building blocks or mixtures thereof can be transformed into complex scaffolds in a convergent and unified strategy. A variety of catalytic systems have been developed and refined over the past decade ranging from late-transition-metal complexes to more sustainable iron- and cobalt-based systems. As the possibilities of this field are slowly unfolding, this area of research will contribute considerably to provide solutions to yet unmet synthetic challenges.
publication.page.subject
Citation
ACS Cent. Sci. 2018, 4, 2, 153–165
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc/4.0/