Publication: ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response
Authors
Xiaozeng, Lin ; Judy, Yan ; Damu, Tang
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
DNA damage response (DDR) is the critical
surveillance mechanism in maintaining genome
integrity. The mechanism activates checkpoints to
prevent cell cycle progression in the presence of DNA
lesions, and mediates lesion repair. DDR is coordinated
by three apical PI3 kinase related kinases (PIKKs),
including ataxia-telangiectasia mutated (ATM), ATM-
and Rad3-related (ATR), and DNA-PKcs (the catalytic
subunit of the DNA dependent protein kinase). These
kinases are activated in response to specific DNA
damage or lesions, resulting in checkpoint activation and
DNA lesion repair. While it is clear that the pathways of
ATM, ATR, and DNA-PK are the core components of
DDR, there is accumulating evidence revealing the
involvement of other cellular pathways in regulating
DDR; this is in line with the concept that in addition to
being a nuclear event DDR is also a cellular process.
One of these pathways is the extracellular signal-
regulated kinase (ERK) MAPK (mitogen-activated
protein kinase) pathway. ERK is a converging point of
multiple signal transduction pathways involved in cell
proliferation, differentiation, and apoptosis. Adding to
this list of pathways is the recent development of ERK in
DDR. The ERK kinases (ERK1 and ERK2) contribute to
the proper execution of DDR in terms of checkpoint
activation and the repair of DNA lesions. This review
summarizes the contributions of ERK to DDR with
emphasis on the relationship of ERK kinases with the
activation of ATM, ATR, and DNA-PKcs.
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Citation
Histology and Histopathology, vol. 28, nº 12 (2013)
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