Publication:
Prognostic value of microRNA-20b expression level in patients with prostate cancer

Simple item page
dc.contributor.authorZhang, Rongkui
dc.contributor.authorLi, Fuwei
dc.contributor.authorWang, Yuchong
dc.contributor.authorYao, Ming
dc.contributor.authorChi, Changliang
dc.date.accessioned2022-11-30T09:40:32Z
dc.date.available2022-11-30T09:40:32Z
dc.date.issued2020
dc.description.abstractBackground. miR-20b is a member of the miR-106a-363 gene cluster located in the mammalian X chromosome, the larger miR-17 family, and the miR-17- 92 and miR-106b-25 gene clusters. Previous studies have indicated that miR-20b may function as oncogene or tumor suppressor in different types of cancers. The present study analyzed the association between miR-20b and clinicopathological characteristics of patients with prostate cancer. Methods. A total of 127 pairs of prostate cancer tissue samples and adjacent prostate tissue samples were collected from April 2013 to March 2018. The associations between miR-20b expression levels and clinicopathological factors were assessed using the χ 2‑test. Survival was estimated using the Kaplan-Meier method, and the differences in survival according to miR-20b expression were compared using the log-rank test. Prognostic values of miR-20b expression and clinical outcomes were evaluated by Cox regression analysis. Results. The relative expression of miR-20b in prostate cancer tissues was significantly higher than that in adjacent noncancerous prostate tissues (P<0.001). miR-20b expression was observed to be significantly associated with Gleason score (P<0.001), lymph node metastasis (P<0.001), and TNM stage (P=0.002). The log-rank test indicated that patients with increased miR- 20b expression experienced poor overall survival (P=0.037). Multivariate Cox regression analysis showed that miR-20b expression level (HR=2.181, 95% CI: 1.772-9.021, P=0.016) was an independent factor in predicting the overall survival of prostate cancer patients. Conclusion. The present study demonstrated that tissue miR-20b expression level could be a promising biomarker of prognosis in prostate cancer.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.citationHistology and Histopathology Vol. 35, nº8 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-216
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126092
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMicroRNA-20bes
dc.subjectMultivariate Cox regression analysises
dc.subjectExpressiones
dc.subjectPrognosises
dc.subjectProstate canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePrognostic value of microRNA-20b expression level in patients with prostate canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Zhang-35-827-831-2020.pdf
Size:
993.68 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.35, nº8 (2020)