Publication:
Prognostic value of microRNA-20b expression level in patients with prostate cancer

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Zhang-35-827-831-2020.pdf(993.68 KB)
Date
2020
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Authors
Zhang, Rongkui ; Li, Fuwei ; Wang, Yuchong ; Yao, Ming ; Chi, Changliang
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-216
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info:eu-repo/semantics/article
Description
Abstract
Background. miR-20b is a member of the miR-106a-363 gene cluster located in the mammalian X chromosome, the larger miR-17 family, and the miR-17- 92 and miR-106b-25 gene clusters. Previous studies have indicated that miR-20b may function as oncogene or tumor suppressor in different types of cancers. The present study analyzed the association between miR-20b and clinicopathological characteristics of patients with prostate cancer. Methods. A total of 127 pairs of prostate cancer tissue samples and adjacent prostate tissue samples were collected from April 2013 to March 2018. The associations between miR-20b expression levels and clinicopathological factors were assessed using the χ 2‑test. Survival was estimated using the Kaplan-Meier method, and the differences in survival according to miR-20b expression were compared using the log-rank test. Prognostic values of miR-20b expression and clinical outcomes were evaluated by Cox regression analysis. Results. The relative expression of miR-20b in prostate cancer tissues was significantly higher than that in adjacent noncancerous prostate tissues (P<0.001). miR-20b expression was observed to be significantly associated with Gleason score (P<0.001), lymph node metastasis (P<0.001), and TNM stage (P=0.002). The log-rank test indicated that patients with increased miR- 20b expression experienced poor overall survival (P=0.037). Multivariate Cox regression analysis showed that miR-20b expression level (HR=2.181, 95% CI: 1.772-9.021, P=0.016) was an independent factor in predicting the overall survival of prostate cancer patients. Conclusion. The present study demonstrated that tissue miR-20b expression level could be a promising biomarker of prognosis in prostate cancer.
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MicroRNA-20b , Multivariate Cox regression analysis , Expression , Prognosis , Prostate cancer
Citation
Histology and Histopathology Vol. 35, nº8 (2020)
URI
http://hdl.handle.net/10201/126092
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Histology and histopathology Vol.35, nº8 (2020)
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