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Cytogenetic analysis and morphology of malignant nuclear vlimata. The life cycle of malignant cells

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dc.contributor.authorLogothetou-Rella, H.es
dc.date.accessioned2011-02-01T09:18:38Z
dc.date.available2011-02-01T09:18:38Z
dc.date.issued1994
dc.description.abstractThe karyotype of malignant nuclear vlimata (NVs) was investigated with the in situ and chromosomal spreading techniques. NV metaphases were recognised by the head with tail morphology, kept in situ and evaluated by the chromosomal spreading technique. It was shown that malignant NVs were produced by random, uncontrolled meiosis. NVs contain and carry single, hypodiploid, haploid, hypohaploid, hyperdiploid and atypical sets of chromosomes. NVs are unstable parasitic cellular elements, invading the cytoplasm or the nucleus of host cells, extruding and implanting their chromosomes in the host cell upon contact. Within a malignant cell culture, NVs play the role of chromosomal donors and host cells of chromosomal recipients. NVs were identified as episomatic on host cell nuclei or incorporated into host cell metaphases. The observations are discusssed in terms of fertilization, vira1 infection and apoptosis. Comparison of malignant NVs with phytohaemagglutinin (PHA)-activated lymphocytic NVs is provided, as well as the life cycle of the malignant cells as follows: meiosis invasion Malignant cell - NVs - recipient host cell - hybrid cells NVs formationes
dc.formatapplication/pdfes
dc.format.extent17es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18536
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCytogeneticses
dc.subjectMeiosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiologíaes
dc.titleCytogenetic analysis and morphology of malignant nuclear vlimata. The life cycle of malignant cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 9, nº 4 (1994)