Publication: Cytogenetic analysis and morphology of malignant nuclear vlimata. The life cycle of malignant cells
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Date
1994
Authors
Logothetou-Rella, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The karyotype of malignant nuclear vlimata
(NVs) was investigated with the in situ and
chromosomal spreading techniques. NV metaphases
were recognised by the head with tail morphology, kept
in situ and evaluated by the chromosomal spreading
technique. It was shown that malignant NVs were
produced by random, uncontrolled meiosis. NVs contain
and carry single, hypodiploid, haploid, hypohaploid,
hyperdiploid and atypical sets of chromosomes. NVs
are unstable parasitic cellular elements, invading the
cytoplasm or the nucleus of host cells, extruding and
implanting their chromosomes in the host cell upon
contact. Within a malignant cell culture, NVs play
the role of chromosomal donors and host cells of
chromosomal recipients. NVs were identified
as episomatic on host cell nuclei or incorporated
into host cell metaphases. The observations are
discusssed in terms of fertilization, vira1 infection and
apoptosis. Comparison of malignant NVs with phytohaemagglutinin
(PHA)-activated lymphocytic NVs is
provided, as well as the life cycle of the malignant cells
as follows:
meiosis invasion
Malignant cell - NVs - recipient host
cell - hybrid cells NVs formation
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