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Paneth cells are also target of the ribotoxic lectin nigrin b

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dc.contributor.authorJiménez, Pilar
dc.contributor.authorGayoso, Manuel José
dc.contributor.authorGarrosa, Manuel
dc.contributor.authorCórdoba-Díaz, Damián
dc.contributor.authorCabrero, Patricia
dc.contributor.authorTejero, Jesús
dc.contributor.authorAracil, Mónica
dc.contributor.authorGirbés, Tomás
dc.date.accessioned2019-07-19T10:17:44Z
dc.date.available2019-07-19T10:17:44Z
dc.date.issued2014
dc.description.abstractRibosome-inactivating lectins (RILs) are AB type toxins like ricin whose molecular target is the large rRNA of eukaryotic ribosome. Administration of lethal doses of the RIL nigrin b isolated from elderberry (Sambucus nigra L.) bark triggers specific intestinal derangement. The aim of the present research was to explore the early effects of a lethal dose of nigrin b (16 mg/kg body weight) on the small intestine using light and electron microscopy to ascertain intestinal epithelium changes. 6 h after nigrin administration, the small intestine crypts began to show signs of damage with cells appearing at different stages of apoptosis. 16 h after injection crypts appeared more impaired, including the derangement of Paneth cells. The novelty of our results is that the Paneth cells in the small intestine in addition to stem cells are the early cellular targets for nigrin b.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 8, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/73941
dc.languageenges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPaneth cellses
dc.subjectNigrin bes
dc.subjectLectines
dc.subjectRIPes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titlePaneth cells are also target of the ribotoxic lectin nigrin bes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 8 (2014)